An often asked question when implementing NFS based storage is what do these advanced settings represent you are recommending me to change?
VMware published a great KB article which describes these. For instance:
NFS.HeartbeatMaxFailures
The number of consecutive heartbeat requests that must fail before the server is marked as unavailable.
The KB article does not only explain the separate NFS settings but also how you can calculate how long it can take before ESX marks a NFS share as unavailable. Good stuff, definitely highly recommended!