It is funny that this has come up a few times now, actually for the third time in a month. I had a question if you can mix AMD and Intel hosts in the same cluster. Although nothing stops you from doing this, and vSAN supports this configuration, you need to remember that you cannot live migrate (vMotion) between those hosts, which means that if you have DRS enabled you are seriously crippling the cluster as it makes balance resource much more complex.
You are creating a Franken cluster when mixing AMD and Intel. You may ask yourself, why would anyone want to do this in the first place? Well, you could do this for migration purposes for instance. If you use vSAN iSCSI Services for instance, this could be a way to migrate those iSCSI LUNs from old hosts to new host. How? Well, simply add the new hosts to the cluster, place the old hosts into maintenance, and make sure to migrate storage. Do note, all the VMs (or containers) will have to be powered off, and powered on again manually on the new hosts, as a result of moving from Intel to AMD (or the other way around).
If you do end up doing this for migration purposes, please ensure it is for the shortest time possible. Please avoid running with a Franken cluster for multiple days, weeks, or, god forbid, months. Nothing good will come out of it, and your VMs may become little monsters!
