I just had a discussion with someone who had to disable the vSAN service, while the cluster was running a production workload. They had all their VMs running on 3rd party storage, so vSAN was empty, but when they went to the vSAN Configuration UI the “Turn Off” option was grayed out. The reason this option is grayed out is that vSphere HA was enabled. This is usually the case for most customers. (Probably 99.9%.) If you need to turn off vSAN, make sure to temporarily disable vSphere HA first, and of course enable it again after you turned off vSAN! This ensures that HA is reconfigured to use the Management Network instead of the vSAN Network.
Another thing to consider, it could be that you manually configured the “HA Isolation Address” for the vSAN Network, make sure to also change that to an IP address on the Management Network again. Lastly, if there’s still anything stored on vSAN, this will be inaccessible when you disable the vSAN service. Of course, if nothing is running on vSAN, then there will be no impact to the workload.